Evaluation of Toll-like receptors expression in terms of colon cancer

نویسندگان

چکیده

Purpose of the study . To evaluate number cells with CD45 +/- phenotype expressing Toll-like receptors (TLRs) in tissues tumor, peritumoral area and resection line colon cancer (CC) various tumor locations. Materials methods The included 50 patients CC. All underwent surgery as primary treatment, tissue material was collected from patients. Expression TLRs (2, 3, 4, 8, 9) on + , - cell populations determined by flow cytometry suspensions obtained (1–3 cm tumor) (~10 further calculation percentage corresponding total cells. Results An analysis left-sided tumors showed lower TLR4, compared to rightsided tumors, 38 % 25 %. A comparative TLR 2, 4 their decrease 81 87 %, respectively, right-sided tumors. assessment data perifocal zone ones, demonstrated a that express 61 Resection statistically significant increase 205 55 respectively. decreased 3 9 did not reveal differences. Conclusions Lower phenotypes 8 tissues, cancer.

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ژورنال

عنوان ژورنال: Issledovaniâ i praktika v medicine

سال: 2022

ISSN: ['2409-2231', '2410-1893']

DOI: https://doi.org/10.17709/2410-1893-2022-9-4-6